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Hypoxia activates AMP-activated protein kinase (AMPK) by inhibiting mitochondrial OXPHOS, which in turn inhibits the PASMCs K v 1.5 channel, inducing a hyperproliferative and anti-apoptotic phenotype in PASMCs (Moral-Sanz et al., 2016)

CHNPATH

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The complexity of patient stratification and personalized treatment further exacerbates cost-effective challenges