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For these reasons, new therapies are urgently needed and drug repurposing seems an affordable option ( Different PDE isoenzymes have been proposed as cancer therapeutic targets, but only PDE5 high levels have been found in different types of cancer ( In this section, we will discuss about the efficacy and underlying cellular mechanisms of the family of PDE5 inhibitors in the field of oncology as repositioning drugs
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This particular study focused on glutamate levels in the basal ganglia after previous studies discovered that hepatitis C treatments stimulated inflammation, depressive symptoms, and increased glutamate in the basal ganglia
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