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These in vitro results have been further validated in murine models of malaria infection and rheumatoid arthritis, where G6PD-d or inhibition leads to less severe proinflammatory responses to stimulation marked by reduced Th1 and Th17 differentiation, decreased proatherogenic cytokines IL-1β, IL-6, IL-12, and TNFɑ, and no impact on IL-10 and TGFβ (classically Treg-derived) 120,121,122,123,124
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In 2015, researchers used mice to investigate the efficacy of mRNA vaccines injected intradermally, intraperitoneally, subcutaneously, intramuscularly, and intravenously
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