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Conclusion In conclusion, COVID-19 positive patients display an alteration in the metabolism of carnitines, ketone bodies, fatty acids, LPC/PC, tryptophan, bile acids, purines and omeprazole, suggesting metabolites as 3-hydroxibutirate, linoleic acid, LPC (14:0 and 18:2), LPE (22:6), kynurenic acid and tryptophan as potential biomarkers of clinical severity