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Their FAO suppression leads to reduced fatty acid breakdown and lipid accumulation, forming โlipid-laden macrophages.โ These macrophages have severely impaired phagocytic function and cannot effectively clear apoptotic cells, foreign bodies, and cigarette smoke particles, further exacerbating the stability of the inflammatory microenvironment
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mTORC1 does not directly โselectโ a specific cell death pathway but rather modulates cellular conditions, such as energy status, redox balance, and autophagy activity, that favor or suppress distinct forms of cell death