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[19] However, it's important to exercise caution in supplement intake, as excessive levels of selenium (Se) and vitamin E, despite their essential antioxidant functions, may potentially hinder collagen synthesis [19] [20] [21]

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In addition, modifying the “do not eat me” signal marker on nanocarriers, such as the CD47 (a transmembrane protein) on the surface of exosomes, can interact with the receptor signal regulatory protein alpha (SIRP alpha), effectively inhibiting macrophage-mediated phagocytosis and further reducing immune clearance (Cheng et al., 2021)