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Furthermore, in general, reported side effects for coenzyme Q10 are minimal, including nausea and diarrhea.[10] Conclusions According to results, Co-enzyme Q10, with fewer side effects and comparable therapeutic effects, especially in the long term, could be a good drug for prophylactic treatment of migraine headaches and a potential one for substituting amitriptyline, a widely accepted drug

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However, a more localized synaptic expression of MET in the adult brain was indeed shown (Tyndall and Walikonis, 2006, 2007)