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J Gerontol B Psychol Sci Soc Sci 2020;75(7):1563‐1572

PA 5505

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Introduction The gastrointestinal (GI) tract, with a surface area of about 40 m 2 , is one of the largest interfaces between the environment and the internal milieu of the body ( In the present review, we will summarize current evidence on the interplay between the IEB and immune system and microbiota and their involvement in GI pathological conditions including IBS, IBD, and gluten-related disorders