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Dosage Protocols Clinical trials employed structured dose-escalation protocols to manage gastrointestinal tolerability: Starting dose: 0.5 mg weekly (the lowest dose used in Phase 2 dose-ranging) Escalation schedule: Dose increases every 4 weeks, with slower escalation (6–8 weeks per step) recommended for those experiencing GI side effects

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This process involves a specific transmembrane nucleoside carrier system that is reversible, nonconcentrative, and bidirectionally symmetrical