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These findings suggest that enhanced mitophagy reduces cytoplasmic free mtDNA levels, thereby mitigating inflammation in Tibetan-specific M9a+sh EPAS1 cells

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The concentration of ethanol solution varied with the modeling time, increasing from 5–20% (mice were offered with 5% ethanol (v/v) for 1 week, then 10% ethanol (v/v) for the next 2 weeks, and 15% ethanol (v/v) for the next 3 weeks, finally animals had access to 20% ethanol (v/v) for last 4 weeks)

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