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A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)

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Studies on animal models and humans have shown that G6PD deficiency increases blood pressure, potentially contributing to the premature development of arterial lesions [13, 15, 16]